Diffuse idiopathic skeletal hyperostosis: a review

  • Reuven Mader | mader_r@clalit.org.il Rheumatology, Ha'Emek Medical Center, Afula, Israel. https://orcid.org/0000-0001-7904-8506
  • Daniela Marotto Rheumatology Unit, ASSL Olbia ATS Sardegna, Italy.
  • Alberto Batticciotto Rheumatology Unit, Internal Medicine Department, ASST Settelaghi, Ospedale Di Circolo - Fondazione Macchi, Varese, Italy.
  • Georgios Filippou Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, Milan, Italy.
  • Amir Bieber Rheumatology, Ha'Emek Medical Center, Afula, Israel.
  • Irina Novofastovski Rheumatology, Ha'Emek Medical Center, Afula, Israel.
  • Valeria Giorgi Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, Milan, Italy.
  • Marina Carotti Radiology Department, Polytechnic University of Marche, Ancona, Italy.
  • Fausto Salaffi Rheumatological Clinic, Polytechnic University of Marche, Ancona, Italy.
  • Piercarlo Sarzi Puttini Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, Milan, Italy.

Abstract

Coined in 1975 by Resnick et al., diffuse idiopathic skeletal hyperostosis describes a systemic condition that is mainly characterized by flowing ossification of the spine and, less frequently, peripheral entheses. Its overall incidence is 6-12%, but it is more frequently observed in males than in females and subjects aged >50 years, and its increased prevalence in people aged >70 years suggests that the course of the disease begins between the third and fifth decade of life but its clinical manifestations do not appear until later. Its pathogenesis and etiology remain unknown, but it has been reported to be associated with a number of genetic, metabolic, and constitutional factors. The aim of this review is to describe the main features of the disease and stimulate research into its pathogenesis, prevention, and treatment.

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Published
2021-01-11
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Section
Reviews
Keywords:
Diffuse idiopathic skeletal hyperostosis, metabolic syndrome, clinical manifestations, radiographic features.
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How to Cite
Mader, R., Marotto, D., Batticciotto, A., Filippou, G., Bieber, A., Novofastovski, I., Giorgi, V., Carotti, M., Salaffi, F., & Sarzi Puttini, P. (2021). Diffuse idiopathic skeletal hyperostosis: a review. Beyond Rheumatology, 2(3), 67-73. https://doi.org/10.4081/br.2020.52

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