The evidence of surgery delay after viscosupplementation is increasing

https://doi.org/10.4081/br.2020.38

Authors

  • Gianfranco Gigliucci Operative Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, Rome, Italy.
  • Giovanni Iolascon Department of Medical and Surgical Specialties and Dentistry, University of Campania Luigi Vanvitelli, Naples; SI G.U.I.D.A. (Società Italiana per la Gestione Unificata ed Interdisciplinare del Dolore muscolo-scheletrico e dell’Algodistrofia), Italy.
  • Biagio Moretti SI G.U.I.D.A. (Società Italiana per la Gestione Unificata ed Interdisciplinare del Dolore muscolo-scheletrico e dell’Algodistrofia); Orthopaedic and Trauma Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, University of Bari Aldo Moro, AOU Consorziale Policlinico, Bari, Italy.
  • Umberto Tarantino SI G.U.I.D.A. (Società Italiana per la Gestione Unificata ed Interdisciplinare del Dolore muscolo-scheletrico e dell’Algodistrofia); Department of Orthopaedics, University of Rome Tor Vergata, Rome, Italy. https://orcid.org/0000-0003-0330-2189
  • Luca Gallelli Department of Health Science, School of Medicine, University of Catanzaro, Catanzaro, Italy.
  • Marco Paoletta Department of Medical and Surgical Specialties and Dentistry, University of Campania Luigi Vanvitelli, Naples; SI G.U.I.D.A. (Società Italiana per la Gestione Unificata ed Interdisciplinare del Dolore muscolo-scheletrico e dell’Algodistrofia), Italy. https://orcid.org/0000-0002-3291-9738
  • Giovanna Picarelli Operative Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, Rome, Italy. https://orcid.org/0000-0002-9280-8853
  • Alberto Migliore | migliore.alberto60@gmail.com Operative Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, Rome; SI G.U.I.D.A. (Società Italiana per la Gestione Unificata ed Interdisciplinare del Dolore muscolo-scheletrico e dell’Algodistrofia), Italy. https://orcid.org/0000-0002-7631-890X

Abstract

Osteoarthritis (OA) is a widespread disease throughout the world and prosthetic replacement is considered an effective and definitive treatment. However, some patients do not want or cannot undergo this type of invasive procedure due to the risk of complications. Besides, this kind of surgery is a very expensive treatment for the healthcare system. Real life studies have shown, with growing evidence, that repeated cycles of intra-articular injections of hyaluronic acid (HA) resulted in a significant reduction in pain symptoms as well as an improvement in joint function. Moreover, an important reduction in analgesics consumption was observed. Some studies have shown a delay of total knee replacement (TKR) for up to 2 years. There is minimal data available about the impact of HA injections on the delay of total hip replacement (THR). This review has also evaluated, in addition to clinical research studies, several papers with data from administrative databases suggesting that viscosupplementation possesses the potential to delay or obviate the need for surgery in patients with knee or hip OA. Further studies are necessary to understand the predictors of response, the diversity of response to different HA products, the appropriate dosage and cyclicity in relation to the radiological and clinical stage of the disease.

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References

Trojian TH, Concoff AL, Joy SM, Hatzenbuehler JR, Saulsberry WJ, Coleman CI. AMSSM scientific statement concerning viscosupplementation injections for knee osteoarthritis: importance for individual patient outcomes. Br J Sports Med. 2016;50(2):84-92. DOI: https://doi.org/10.1136/bjsports-2015-095683

Bruyère O, Honvo G, Veronese N, Arden NK, Branco J, Curtis EM, Al-Daghri NM, Herrero-Beaumont G, Martel-Pelletier J, Pelletier JP, Rannou F, Rizzoli R, Roth R, Uebelhart D, Cooper C, Reginster JY. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019;49(3):337-350. DOI: https://doi.org/10.1016/j.semarthrit.2019.04.008

Conrozier T, Monfort J, Chevalier X, Raman R, Richette P, Diraçoglù D, Bard H, Baron D, Jerosch J, Migliore A, Henrotin Y. EUROVISCO Recommendations for Optimizing the Clinical Results of Viscosupplementation in Osteoarthritis. Cartilage. 2020;11(1):47-59. DOI: https://doi.org/10.1177/1947603518783455

(4)Win Min Oo, Xiaoqian Liu, David J Hunter Pharmacodynamics, efficacy, safety and administration of intra-articular therapies for knee osteoarthritis. Expert Opin Drug Metab Toxicol . 2019;15(12):1021-1032. DOI: https://doi.org/10.1080/17425255.2019.1691997

Roy D Altman, Asheesh Bedi, Jon Karlsson, Parag Sancheti, Emil Schemitsch Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. Am J Sports Med Product 2016 Aug; 44(8):2158-65 DOI: https://doi.org/10.1177/0363546515609599

Roy Altman, Josh Hackel, Faizan Niazi, Peter Shaw, Mathew Nicholls. Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: A systematic review. Semin Arthritis Rheum. 2018;48(2):168-175. DOI: https://doi.org/10.1016/j.semarthrit.2018.01.009

Maheu E, Rannou F, Reginster J-Y. Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016;45(4 Suppl):S28-33. DOI: https://doi.org/10.1016/j.semarthrit.2015.11.008

Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162(1):46–54. DOI: https://doi.org/10.7326/M14-1231

Mandl LA, Losina E. Relative efficacy of knee osteoarthritis treatments: are all placebos created equal? Ann Intern Med. 2015;162(1):71–2. DOI: https://doi.org/10.7326/M14-2636

Waddell DD, Bricker DC. Total knee replacement delayed with Hylan G-F 20 use in patients with grade IV osteoarthritis. J Manag Care Pharm. 2007;13(2):113–21.

Ong KL, Runa M, Lau E, Altman R. Is Intra-Articular Injection of Synvisc Associated with a Delay to Knee Arthroplasty in Patients with Knee Osteoarthritis? Cartilage. 2018;1947603518775792. DOI: https://doi.org/10.1177/1947603518775792

Dasa V, Lim S, Heeckt P. Real-World Evidence for Safety and Effectiveness of Repeated Courses of Hyaluronic Acid Injections on the Time to Knee Replacement Surgery. Am J Orthop. 2018;47(7). DOI: https://doi.org/10.12788/ajo.2018.0058

Turajane T, Amphansap T, Labpiboonpong V, Maungsiri S. Total knee replacement following repeated cycles of intra-articular sodium hyaluronate (500-730 Kda) in failed conservative treatment of knee osteoarthritis: a 54-month follow-up. J Med Assoc Thai. 2009;92 Suppl 6:S63-68.

Waddell DD, Joseph B. Delayed Total Knee Replacement with Hylan G-F 20. J Knee Surg. 2016;29(2):159–68.

Altman R, Lim S, Steen RG, Dasa V. Hyaluronic Acid Injections Are Associated with Delay of Total Knee Replacement Surgery in Patients with Knee Osteoarthritis: Evidence from a Large U.S. Health Claims Database. PLoS ONE. 2015;10(12):e0145776. DOI: https://doi.org/10.1371/journal.pone.0145776

Altman R, Fredericson M, Bhattacharyya SK, Bisson B, Abbott T, Yadalam S, et al. Association between Hyaluronic Acid Injections and Time-to-Total Knee Replacement Surgery. J Knee Surg. 2016;29(7):564–70. DOI: https://doi.org/10.1055/s-0035-1568992

Shewale AR, Barnes CL, Fischbach LA, Ounpraseuth ST, Painter JT, Martin BC. Comparison of Low-, Moderate-, and High-Molecular-Weight Hyaluronic Acid Injections in Delaying Time to Knee Surgery. J Arthroplasty. 2017;32(10):2952-2957.e21. DOI: https://doi.org/10.1016/j.arth.2017.04.041

van den Bekerom MPJ, Lamme B, Sermon A, Mulier M. What is the evidence for viscosupplementation in the treatment of patients with hip osteoarthritis? Systematic review of the literature. Arch Orthop Trauma Surg. 2008;128(8):815–23. DOI: https://doi.org/10.1007/s00402-007-0447-z

Migliore A, Bizzi E, Massafra U, Bella A, Piscitelli P, Laganà B, et al. The impact of treatment with hylan G-F 20 on progression to total hip arthroplasty in patients with symptomatic hip OA: a retrospective study. Curr Med Res Opin. 2012;28(5):755–60. DOI: https://doi.org/10.1185/03007995.2011.645563

Migliore A, Bella A, Bisignani M, Calderaro M, De Amicis D, Logroscino G, et al. Total hip replacement rate in a cohort of patients affected by symptomatic hip osteoarthritis following intra-articular sodium hyaluronate (MW 1,500-2,000 kDa) ORTOBRIX study. Clin Rheumatol. 2012;31(8):1187–96. DOI: https://doi.org/10.1007/s10067-012-1994-4

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Published
2020-12-16
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Section
Expert Opinion
Keywords:
Viscosupplementation, osteoarthritis, hyaluronic acid, total knee replacement.
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How to Cite
Gigliucci, G., Iolascon, G., Moretti, B., Tarantino, U., Gallelli, L., Paoletta, M., Picarelli, G., & Migliore, A. (2020). The evidence of surgery delay after viscosupplementation is increasing. Beyond Rheumatology, 2(3), 79–82. https://doi.org/10.4081/br.2020.38