Long-term outcomes in a cohort of patients with juvenile idiopathic arthritis: serological phenotypes and disease activity in adulthood

  • Marta Priora | marta.priora@gmail.com Division of Rheumatology, University Hospital Città della Salute e della Scienza, Turin, Italy. https://orcid.org/0000-0002-9194-9179
  • Tilde Manetta Division of Laboratory Medicine, University Hospital Città della Salute e della Scienza, Turin, Italy. https://orcid.org/0000-0001-5584-8883
  • Simone Parisi Division of Rheumatology, University Hospital Città della Salute e della Scienza, Turin, Italy.
  • Maria Chiara Ditto Division of Rheumatology, University Hospital Città della Salute e della Scienza, Turin, Italy. https://orcid.org/0000-0001-5025-287X
  • Angela Laganà Division of Rheumatology, University Hospital Città della Salute e della Scienza, Turin, Italy.
  • Clara Lisa Peroni Division of Rheumatology, University Hospital Città della Salute e della Scienza, Turin, Italy.
  • Giulio Mengozzi Division of Laboratory Medicine, University Hospital Città della Salute e della Scienza, Turin, Italy. https://orcid.org/0000-0003-0431-8369
  • Enrico Fusaro Division of Rheumatology, University Hospital Città della Salute e della Scienza, Turin, Italy. https://orcid.org/0000-0001-9888-2563

Abstract

In a scenario characterised by diagnostic and therapeutic improvements, an increasing number of juvenile idiopathic arthritis (JIA) patients require ongoing care into adulthood. Deepening the long-term study on JIA is fundamental in order to expand pathogenic knowledge, optimize treatment options and favour an active communication between paediatric and adult care-specialists. This study dealt with adult patients affected by JIA. The main objectives were: i) to analyse the serological profile to examine possible seroconversions in adults; ii) to evaluate the association between antibodies and disease activity; iii) to investigate the correlation between antibodies, diagnostic subgroups and disease activity. Sixty-eight patients were selected. A positive rheumatoidfactor and anti-citrullinated-peptides-antibodies tests were found both at diagnosis and in adulthood (P<0.05). Their association with the polyarticular subgroup persisted in the long term (P<0.05) and they associated with a higher disease activity in adulthood assessed with both JADAS27 and SDAI. At diagnosis, 45.6% of patients were ANA positive, while only 13.2% stayed positive in adulthood (P<0.05). These results may highlight the need to verify in adulthood the presence of ANA in those patients with JIA with ANA positivity at diagnosis.

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Published
2019-12-20
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Original Articles
Keywords:
Adulthood, juvenile idiopathic arthritis, long-term outcome, transition of care.
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How to Cite
Priora, M., Manetta, T., Parisi, S., Ditto, M. C., Laganà, A., Peroni, C. L., Mengozzi, G., & Fusaro, E. (2019). Long-term outcomes in a cohort of patients with juvenile idiopathic arthritis: serological phenotypes and disease activity in adulthood. Beyond Rheumatology, 1(2), 63-67. https://doi.org/10.4081/br.2019.25