Kidney involvement in systemic sclerosis

  • Angelo De Cata | angelo.decata@libero.it Department of Internal Medicine and Rheumatology Unit, Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo (FG), Italy.
  • Michele Inglese Department of Internal Medicine and Rheumatology Unit, Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo (FG), Italy.
  • Francesca Molinaro Department of Internal Medicine and Rheumatology Unit, Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo (FG), Italy.
  • Renato Carignola Scleroderma Unit, University Hospital San Luigi Gonzaga, Orbassano (TO), Italy.

Abstract

Kidney involvement in systemic sclerosis (SSc) is primarily manifested by scleroderma renal crisis (SRC). More than 30 years ago, it was the main cause of death in these patients. The use of AC inhibitors has modified the prognosis and nowadays SRC has become a much more easily treatable complication of SSc. Furthermore, although there are still many patients who do not survive this complication, the early diagnosis and prompt therapy of SRC can have an excellent outcome. Renal abnormalities independent of SRC are possible but are attributed to different pathogenetic mechanisms. Further understanding of pathogenesis of SRC may lead to additional improvement in the therapy of this serious complication.

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Published
2019-05-06
Section
Reviews
Keywords:
Systemic sclerosis, scleroderma renal crisis, prognosis, therapy.
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How to Cite
De Cata, A., Inglese, M., Molinaro, F., & Carignola, R. (2019). Kidney involvement in systemic sclerosis. Beyond Rheumatology, 1(1), 3-8. https://doi.org/10.4081/br.2019.1